Ontology highlight
ABSTRACT:
SUBMITTER: Rayalu DJ
PROVIDER: S-EPMC3282261 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Rayalu Daddam Jayasimha DJ Selvaraj Chandrabose C Singh Sanjeev Kumar SK Ganeshan Ramakrishan R Kumar Nagapatla Udaya NU Seshapani Panthangi P
Bioinformation 20120120 2
In cardiovascular system, activation of Endothelin receptors causes vasoconstriction which leads to Pulmonary Arterial Hypertension (PAH). Endothelin receptor antagonism has emerged as an important therapeutic strategy in pulmonary arterial hypertension. Bosentan is intended to affect vasoconstriction, hypertrophic and fibrotic effects by blocking the actions of receptors ET(A) and ET(B). In this study we identified the action of Bosentan on endothelin B receptor using docking studies with homol ...[more]