Ontology highlight
ABSTRACT:
SUBMITTER: Donaldson DS
PROVIDER: S-EPMC3282432 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Donaldson D S DS Kobayashi A A Ohno H H Yagita H H Williams I R IR Mabbott N A NA
Mucosal immunology 20120201 2
Many prion diseases are orally acquired. Our data show that after oral exposure, early prion replication upon follicular dendritic cells (FDC) in Peyer's patches is obligatory for the efficient spread of disease to the brain (termed neuroinvasion). For prions to replicate on FDC within Peyer's patches after ingestion of a contaminated meal, they must first cross the gut epithelium. However, the mechanism through which prions are conveyed into Peyer's patches is uncertain. Within the follicle-ass ...[more]