Ontology highlight
ABSTRACT:
SUBMITTER: Richard G
PROVIDER: S-EPMC3282698 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Richard Guilhem G Belta Calin C Julius A Agung AA Amar Salomon S
PloS one 20120220 2
The Toll-Like Receptors (TLRs) are proteins involved in the immune system that increase cytokine levels when triggered. While cytokines coordinate the response to infection, they appear to be detrimental to the host when reaching too high levels. Several studies have shown that the deletion of specific TLRs was beneficial for the host, as cytokine levels were decreased consequently. It is not clear, however, how targeting other components of the TLR pathways can improve the responses to infectio ...[more]