Ontology highlight
ABSTRACT:
SUBMITTER: Cao G
PROVIDER: S-EPMC3282795 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120220 2
Bmi-1, a polycomb transcriptional repressor, is implicated in cell cycle regulation and cell senescence. Its absence results in generalized astrogliosis and epilepsy during the postnatal development, but the underlying mechanisms are poorly understood. Here, we demonstrate the occurrence of oxidative stress in the brain of four-week-old Bmi-1 null mice. The mice showed various hallmarks of neurodegeneration including synaptic loss, axonal demyelination, reactive gliosis and brain mitochondrial d ...[more]