The dispanins: a novel gene family of ancient origin that contains 14 human members.
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ABSTRACT:
SUBMITTER: Sallman Almen M
PROVIDER: S-EPMC3282796 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
The dispanins: a novel gene family of ancient origin that contains 14 human members.
Sällman Almén Markus M Bringeland Nathalie N Fredriksson Robert R Schiöth Helgi B HB
PloS one 20120220 2
The Interferon induced transmembrane proteins (IFITM) are a family of transmembrane proteins that is known to inhibit cell invasion of viruses such as HIV-1 and influenza. We show that the IFITM genes are a subfamily in a larger family of transmembrane (TM) proteins that we call Dispanins, which refers to a common 2TM structure. We mined the Dispanins in 36 eukaryotic species, covering all major eukaryotic groups, and investigated their evolutionary history using Bayesian and maximum likelihood ...[more]
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