Unknown

Dataset Information

0

Bupropion for smoking cessation in African American light smokers: a randomized controlled trial.


ABSTRACT:

Background

Previous research demonstrated the efficacy of sustained release bupropion (bupropion SR) for smoking cessation in whites as well as moderate to heavy (≥10 cigarettes per day [CPD]) African American smokers. We evaluated whether bupropion SR was effective for smoking cessation among African American light smokers (≤10 CPD).

Methods

A randomized, double-blind placebo-controlled trial was conducted from December 27, 2007, to May 13, 2010. All participants were African American light smokers (≤10 CPD), aged 18 years or older. Participants were randomly assigned to receive 300 mg bupropion SR (150 mg once daily for 3 days and then 150 mg twice daily) (n = 270 participants) or placebo (n = 270 participants) for 7 weeks, and up to six sessions of health education counseling. Serum cotinine was measured at baseline (week 0). The primary outcome was salivary cotinine-verified 7-day point prevalence smoking abstinence at week 26; a cut point of 15 ng/mL differentiated smokers from nonsmokers. Salivary cotinine-verified smoking abstinence at end of medication treatment at week 7 was also examined. Odds ratios (OR) for smoking abstinence and 95% confidence intervals (CIs) were calculated using logistic regression models. All statistical tests were two-sided.

Results

Participants at baseline visit (week 0) smoked an average of 8.0 CPD and had a mean serum cotinine level of 275.8 ng/mL (SD = 155.8 ng/mL); most used menthol cigarettes (83.7%) and smoked within 30 minutes of waking (72.2%). After imputing those lost to follow-up as smokers, no statistically significant difference in long-term smoking abstinence rates at week 26 was observed between bupropion SR and placebo groups (13.3% vs 10.0%, OR = 1.39, 95% CI = 0.82 to 2.35, P = .23). Cotinine-verified smoking abstinence rate at end of medication week 7 was higher in the bupropion SR vs placebo group (23.7% vs 9.6%, OR = 2.92, 95% CI = 1.78 to 4.77, P < .001).

Conclusions

Bupropion SR was effective in promoting smoking cessation during the medication phase of treatment but showed no effect on long-term smoking cessation among African American light smokers. More research is needed to identify strategies for sustaining abstinence among African American light smokers.

SUBMITTER: Cox LS 

PROVIDER: S-EPMC3283533 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Bupropion for smoking cessation in African American light smokers: a randomized controlled trial.

Cox Lisa Sanderson LS   Nollen Nicole L NL   Mayo Matthew S MS   Choi Won S WS   Faseru Babalola B   Benowitz Neal L NL   Tyndale Rachel F RF   Okuyemi Kolawole S KS   Ahluwalia Jasjit S JS  

Journal of the National Cancer Institute 20120125 4


<h4>Background</h4>Previous research demonstrated the efficacy of sustained release bupropion (bupropion SR) for smoking cessation in whites as well as moderate to heavy (≥10 cigarettes per day [CPD]) African American smokers. We evaluated whether bupropion SR was effective for smoking cessation among African American light smokers (≤10 CPD).<h4>Methods</h4>A randomized, double-blind placebo-controlled trial was conducted from December 27, 2007, to May 13, 2010. All participants were African Ame  ...[more]

Similar Datasets

| S-EPMC3558614 | biostudies-literature
| S-EPMC4635476 | biostudies-literature
| S-EPMC5017904 | biostudies-literature
| S-EPMC3698861 | biostudies-literature
| S-EPMC8295398 | biostudies-literature
| S-EPMC2518039 | biostudies-other
| S-EPMC3799568 | biostudies-literature
| S-EPMC4606962 | biostudies-literature
| S-EPMC9321212 | biostudies-literature
| S-EPMC9198729 | biostudies-literature