Ontology highlight
ABSTRACT:
SUBMITTER: McLaughlin HP
PROVIDER: S-EPMC3283593 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
McLaughlin Heather P HP Xiao Qiaobin Q Rea Rosemarie B RB Pi Hualiang H Casey Pat G PG Darby Trevor T Charbit Alain A Sleator Roy D RD Joyce Susan A SA Cowart Richard E RE Hill Colin C Klebba Phillip E PE Gahan Cormac G M CG
PloS one 20120221 2
Regulation of iron homeostasis in many pathogens is principally mediated by the ferric uptake regulator, Fur. Since acquisition of iron from the host is essential for the intracellular pathogen Listeria monocytogenes, we predicted the existence of Fur-regulated systems that support infection. We examined the contribution of nine Fur-regulated loci to the pathogenicity of L. monocytogenes in a murine model of infection. While mutating the majority of the genes failed to affect virulence, three mu ...[more]