Ontology highlight
ABSTRACT:
SUBMITTER: Bongfen SE
PROVIDER: S-EPMC3283600 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Bongfen Silayuv E SE Rodrigue-Gervais Ian-Gael IG Berghout Joanne J Torre Sabrina S Cingolani Pablo P Wiltshire Sean A SA Leiva-Torres Gabriel A GA Letourneau Louis L Sladek Robert R Blanchette Mathieu M Lathrop Mark M Behr Marcel A MA Gruenheid Samantha S Vidal Silvia M SM Saleh Maya M Gros Philippe P
PloS one 20120221 2
Cerebral malaria (CM) is a lethal neurological complication of malaria. We implemented a genome-wide screen in mutagenized mice to identify host proteins involved in CM pathogenesis and whose inhibition may be of therapeutic value. One pedigree (P48) segregated a resistance trait whose CM-protective effect was fully penetrant, mapped to chromosome 8, and identified by genome sequencing as homozygosity for a mis-sense mutation (W81R) in the FERM domain of Janus-associated kinase 3 (Jak3). The cau ...[more]