Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC3285101 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Li Bo B Piriz Joaquin J Mirrione Martine M Chung ChiHye C Proulx Christophe D CD Schulz Daniela D Henn Fritz F Malinow Roberto R
Nature 20110201 7335
The cellular basis of depressive disorders is poorly understood. Recent studies in monkeys indicate that neurons in the lateral habenula (LHb), a nucleus that mediates communication between forebrain and midbrain structures, can increase their activity when an animal fails to receive an expected positive reward or receives a stimulus that predicts aversive conditions (that is, disappointment or anticipation of a negative outcome). LHb neurons project to, and modulate, dopamine-rich regions, such ...[more]