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Identification of cancer cell-line origins using fluorescence image-based phenomic screening.

ABSTRACT: Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines.

SUBMITTER: Lee JS

PROVIDER: S-EPMC3285665 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Identification of cancer cell-line origins using fluorescence image-based phenomic screening.

Lee Jun-Seok JS Kim Yun Kyung YK Kim Han Jo HJ Hajar Siti S Tan Yee Ling YL Kang Nam-Young NY Ng Shin Hui SH Yoon Chang No CN Chang Young-Tae YT

PloS one 20120223 2

Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines. ...[more]

PMID: 22384151

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