Ontology highlight
ABSTRACT:
SUBMITTER: Simon K
PROVIDER: S-EPMC3285901 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Simon Kirk K Mukundan Anju A Dewundara Samantha S Van Remmen Holly H Dombkowski Alan A AA Cabelof Diane C DC
Mechanisms of ageing and development 20090811 9
The p53 DNA damage response attenuated with age and we have evaluated downstream factors in the DNA damage response. In old animals p21 protein accumulates in the whole cell fraction but significantly declines in the nucleus, which may alter cell cycle and apoptotic programs in response to DNA damage. We evaluated the transcriptional response to DNA damage in young and old and find 2692 genes are differentially regulated in old compared to young in response to oxidative stress (p<0.005). As anti ...[more]