Ontology highlight
ABSTRACT:
SUBMITTER: Azab AK
PROVIDER: S-EPMC3286211 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Azab Abdel Kareem AK Quang Phong P Azab Feda F Pitsillides Costas C Thompson Brian B Chonghaile Triona T Patton John T JT Maiso Patricia P Monrose Val V Sacco Antonio A Ngo Hai T HT Flores Ludmila M LM Lin Charles P CP Magnani John L JL Kung Andrew L AL Letai Anthony A Carrasco Ruben R Roccaro Aldo M AM Ghobrial Irene M IM
Blood 20111116 6
Interactions between multiple myeloma (MM) cells and the BM microenvironment play a critical role in the pathogenesis of MM and in the development of drug resistance by MM cells. Selectins are involved in extravasation and homing of leukocytes to target organs. In the present study, we focused on adhesion dynamics that involve P-selectin glycoprotein ligand-1 (PSGL-1) on MM cells and its interaction with selectins in the BM microenvironment. We show that PSGL-1 is highly expressed on MM cells an ...[more]