Ontology highlight
ABSTRACT:
SUBMITTER: Malla RR
PROVIDER: S-EPMC3286222 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Malla Rama Rao RR Gopinath Sreelatha S Gondi Christopher S CS Alapati Kiranmai K Dinh Dzung H DH Tsung Andrew J AJ Rao Jasti S JS
Journal of neuro-oncology 20111002 1
Cathepsin B and urokinase plasminogen activator receptor (uPAR) are postulated to play key roles in glioma invasion. Calcineurin is one of the key regulators of mitochondrial-dependent apoptosis, but its mechanism is poorly understood. Hence, we studied subcellular localization of calcineurin after transcriptional downregulation of uPAR and cathepsin B in glioma. In the present study, efficient downregulation of uPAR and cathepsin B increased the translocation of calcineurin A from the mitochond ...[more]