Ontology highlight
ABSTRACT:
SUBMITTER: O'Callaghan K
PROVIDER: S-EPMC3286348 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
O'Callaghan Katie K Lee Lydia L Nguyen Nga N Hsieh Mo-Ying MY Kaneider Nicole C NC Klein Andreas K AK Sprague Kellie K Van Etten Richard A RA Kuliopulos Athan A Covic Lidija L
Blood 20111220 7
The chemokine receptor CXCR4, which normally regulates stromal stem cell interactions in the bone marrow, is highly expressed on a variety of malignant hematologic cells, including lymphoma and lymphocytic leukemias. A new treatment concept has arisen wherein CXCR4 may be an effective therapeutic target as an adjunct to treatment of hematologic neoplasms with chemo- and immunotherapy. In the present study, we developed pepducins, cell-penetrating lipopeptide antagonists of CXCR4, to interdict CX ...[more]