4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.
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ABSTRACT:
SUBMITTER: She QB
PROVIDER: S-EPMC3286650 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.
She Qing-Bai QB Halilovic Ensar E Ye Qing Q Zhen Wei W Shirasawa Senji S Sasazuki Takehiko T Solit David B DB Rosen Neal N
Cancer cell 20100701 1
PIK3CA and PTEN alterations are common in human cancer, but only a fraction of such tumors are dependent upon AKT signaling. AKT independence is associated with redundant activation of cap-dependent translation mediated by convergent regulation of the translational repressor 4E-BP1 by the AKT and ERK pathways. This provides mechanistic bases for the limited activity of AKT and MEK inhibitors in tumors with comutation of both pathways and the profound synergy observed with combined inhibition. Wh ...[more]
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