Ontology highlight
ABSTRACT:
SUBMITTER: Ma P
PROVIDER: S-EPMC3286984 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ma Pengpeng P Pan Hua H Montgomery Rusty L RL Olson Eric N EN Schultz Richard M RM
Proceedings of the National Academy of Sciences of the United States of America 20120105 8
Dramatic changes in chromatin structure and histone modification occur during oocyte growth, as well as a global cessation of transcription. The role of histone modifications in these processes is poorly understood. We report the effect of conditionally deleting Hdac1 and Hdac2 on oocyte development. Deleting either gene has little or no effect on oocyte development, whereas deleting both genes results in follicle development arrest at the secondary follicle stage. This developmental arrest is a ...[more]