Ontology highlight
ABSTRACT:
SUBMITTER: Tsutsumi S
PROVIDER: S-EPMC3287002 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Tsutsumi Shinji S Mollapour Mehdi M Prodromou Chrisostomos C Lee Chung-Tien CT Panaretou Barry B Yoshida Soichiro S Mayer Matthias P MP Neckers Leonard M LM
Proceedings of the National Academy of Sciences of the United States of America 20120206 8
Hsp90 is an essential and highly conserved modular molecular chaperone whose N and middle domains are separated by a disordered region termed the charged linker. Although its importance has been previously disregarded, because a minimal linker length is sufficient for Hsp90 activity, the evolutionary persistence of extensive charged linkers of divergent sequence in Hsp90 proteins of most eukaryotes remains unexplained. To examine this question further, we introduced human and plasmodium native a ...[more]