Ontology highlight
ABSTRACT:
SUBMITTER: Li P
PROVIDER: S-EPMC3287208 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Li Ping P Zhao Yuhao Y Wu Xiaoyan X Xia Minjie M Fang Mingming M Iwasaki Yasumasa Y Sha Jiahao J Chen Qi Q Xu Yong Y Shen Aiguo A
Nucleic acids research 20111107 4
Chronic inflammation impairs metabolic homeostasis and is intimately correlated with the pathogenesis of type 2 diabetes. The pro-inflammatory cytokine IFN-γ is an integral part of the metabolic inflammation circuit and contributes significantly to metabolic dysfunction. The underlying mechanism, however, remains largely unknown. In the present study, we report that IFN-γ disrupts the expression of genes key to cellular metabolism and energy expenditure by repressing the expression and activity ...[more]