Ontology highlight
ABSTRACT:
SUBMITTER: Sica A
PROVIDER: S-EPMC3287223 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20120301 3
Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages undergo M1 (classical) or M2 (alternative) activation, which represent extremes of a continuum in a universe of activation states. Progress has now been made in defining the signaling pathways, transcriptional networks, and epigenetic mechanisms underlying M1-M2 or M2-like polarized activation. Functional skewing of mononucle ...[more]