Ontology highlight
ABSTRACT:
SUBMITTER: Knight JD
PROVIDER: S-EPMC3287957 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Knight James D R JD Hamelberg Donald D McCammon J Andrew JA Kothary Rashmi R
Proteins 20090801 3
Protein kinases are essential signaling molecules with a characteristic bilobal shape that has been studied for over 15 years. Despite the number of crystal structures available, little study has been directed away from the prototypical functional elements of the kinase domain. We have performed a structural alignment of 13 active-conformation kinases and discovered the presence of six water molecules that occur in conserved locations across this group of diverse kinases. Molecular dynamics simu ...[more]