Ontology highlight
ABSTRACT:
SUBMITTER: Allen JL
PROVIDER: S-EPMC3288200 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Allen Jessica L JL Flick Leah M LM Divanovic Senad S Jackson Shaun W SW Bram Richard R Rawlings David J DJ Finkelman Fred D FD Karp Christopher L CL
Journal of immunology (Baltimore, Md. : 1950) 20120130 5
Mechanistic understanding of RP105 has been confounded by the fact that this TLR homolog has appeared to have opposing, cell type-specific effects on TLR4 signaling. Although RP105 inhibits TLR4-driven signaling in cell lines and myeloid cells, impaired LPS-driven proliferation by B cells from RP105(-/-) mice has suggested that RP105 facilitates TLR4 signaling in B cells. In this article, we show that modulation of B cell proliferation by RP105 is not a function of B cell-intrinsic expression of ...[more]