Ontology highlight
ABSTRACT:
SUBMITTER: Lazarou M
PROVIDER: S-EPMC3288275 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Lazarou Michael M Jin Seok Min SM Kane Lesley A LA Youle Richard J RJ
Developmental cell 20120125 2
Mutations in the mitochondrial kinase PINK1 and the cytosolic E3 ligase Parkin can cause Parkinson's disease. Damaged mitochondria accumulate PINK1 on the outer membrane where, dependent on kinase activity, it recruits and activates Parkin to induce mitophagy, potentially maintaining organelle fidelity. How PINK1 recruits Parkin is unknown. We show that endogenous PINK1 forms a 700 kDa complex with the translocase of the outer membrane (TOM) selectively on depolarized mitochondria whereas PINK1 ...[more]