Ontology highlight
ABSTRACT:
SUBMITTER: Seiler MP
PROVIDER: S-EPMC3288314 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Seiler Michael P MP Mathew Rebecca R Liszewski Megan K MK Spooner Chauncey J CJ Barr Kenneth K Meng Fanyong F Singh Harinder H Bendelac Albert A
Nature immunology 20120205 3
Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4(+)CD8(+) thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression in precursors of the natural killer T (NKT) than in cells of conventional lineages. Chromatin immunoprecipitation followed by deep sequencing showed that Egr2 directly bound and ac ...[more]