Ontology highlight
ABSTRACT:
SUBMITTER: Terracciano A
PROVIDER: S-EPMC3288597 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Terracciano Antonio A Piras Maria Grazia MG Lobina Monia M Mulas Antonella A Meirelles Osorio O Sutin Angelina R AR Chan Wayne W Sanna Serena S Uda Manuela M Crisponi Laura L Schlessinger David D
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20111102 8
<h4>Objectives</h4>Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the best known biomarkers of depression. To identify genetic variants associated with serum BDNF, we tested the Val66Met (rs6265) functional variant and conducted a genome-wide association scan (GWAS).<h4>Methods</h4>In a community-based sample (N = 2054; aged 19-101, M = 51, SD = 15) from Sardinia, Italy, we measured serum BDNF concentration and conducted a GWAS.<h4>Results</h4>We estimated the heritabil ...[more]