Ontology highlight
ABSTRACT:
SUBMITTER: Westmoreland JJ
PROVIDER: S-EPMC3288608 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Westmoreland Joby J JJ Drosos Yiannis Y Kelly Jacqueline J Ye Jianming J Means Anna L AL Washington M Kay MK Sosa-Pineda Beatriz B
Developmental dynamics : an official publication of the American Association of Anatomists 20120131 3
<h4>Background</h4>The assembly of distinct proteins into tight junctions results in the formation of a continuous barrier that regulates the paracellular flux of water, ions, and small molecules across epithelia. The claudin protein family encompasses numerous major structural components of tight junctions. These proteins specify the permeability characteristics of tight junctions and consequently, some of the physiological properties of epithelia. Furthermore, defective claudin expression has ...[more]