Ontology highlight
ABSTRACT:
SUBMITTER: Axlund SD
PROVIDER: S-EPMC3288619 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Axlund Sunshine Daddario SD Sartorius Carol A CA
Molecular and cellular endocrinology 20110916 1-2
Progesterone plays an important, if not controversial, role in mammary epithelial cell proliferation and differentiation. Evidence supports that progesterone promotes rodent mammary carcinogenesis under some conditions, progesterone receptors (PR) are necessary for murine mammary gland tumorigenesis, and exogenous progestin use in post-menopausal women increases breast cancer risk. Thus, the progesterone/PR signaling axis can promote mammary tumorigenesis, albeit in a context-dependent manner. A ...[more]