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Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration.


ABSTRACT:

Purpose

To compare plasma levels of oxidative stress biomarkers in patients with age-related macular degeneration (AMD) and controls and to evaluate a potential relationship between biochemical markers of oxidative stress and AMD susceptibility genotypes.

Design

Prospective case-control study.

Methods

Plasma levels of oxidative stress biomarkers were determined in 77 AMD patients and 75 controls recruited from a clinical practice. Cysteine, cystine (CySS), glutathione, isoprostane, and isofuran were measured, and participants were genotyped for polymorphisms in the complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes.

Results

CySS was elevated in cases compared with controls (P = .013). After adjustment for age, sex, and smoking, this association was not significant. In all participants, CySS levels were associated with the CFH polymorphism rs3753394 (P = .028) as well as an 8-allele CFH haplotype (P = .029) after correction for age, gender, and smoking. None of the other plasma markers was related to AMD status in our cohort.

Conclusions

Our investigation of the gene-environment interaction involved in AMD revealed a relationship between a plasma biomarker of oxidative stress, CySS, and CFH genotype. These data suggest a potential association between inflammatory regulators and redox status in AMD pathogenesis.

SUBMITTER: Brantley MA 

PROVIDER: S-EPMC3288635 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Publications

Plasma biomarkers of oxidative stress and genetic variants in age-related macular degeneration.

Brantley Milam A MA   Osborn Melissa P MP   Sanders Barton J BJ   Rezaei Kasra A KA   Lu Pengcheng P   Li Chun C   Milne Ginger L GL   Cai Jiyang J   Sternberg Paul P  

American journal of ophthalmology 20111029 3


<h4>Purpose</h4>To compare plasma levels of oxidative stress biomarkers in patients with age-related macular degeneration (AMD) and controls and to evaluate a potential relationship between biochemical markers of oxidative stress and AMD susceptibility genotypes.<h4>Design</h4>Prospective case-control study.<h4>Methods</h4>Plasma levels of oxidative stress biomarkers were determined in 77 AMD patients and 75 controls recruited from a clinical practice. Cysteine, cystine (CySS), glutathione, isop  ...[more]

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