Ontology highlight
ABSTRACT:
SUBMITTER: Mengeling BJ
PROVIDER: S-EPMC3288673 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Mengeling Brenda J BJ Goodson Michael L ML Bourguet William W Privalsky Martin L ML
Molecular and cellular endocrinology 20120112 2
The SMRT and NCoR corepressors bind to, and mediate transcriptional repression by, many nuclear receptors. Both SMRT and NCoR are expressed by alternative mRNA splicing, generating a series of structurally and functionally distinct corepressor "variants". We report that a splice variant of SMRT, SMRTε, recognizes a restricted subset of nuclear receptors. Unlike the other corepressor variants characterized, SMRTε possesses only a single receptor interaction domain (RID) and exhibits an unusual sp ...[more]