Ontology highlight
ABSTRACT:
SUBMITTER: Nichols DB
PROVIDER: S-EPMC3288800 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
European journal of medicinal chemistry 20120112
Structure-based studies led to the identification of a constrained derivative of S-trityl-l-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C virus (HCV) NS5B polymerase. A panel of STLC derivatives were synthesized and investigated for their activity against HCV NS5B. Three STLC derivatives, 9, F-3070, and F-3065, were identified as modest HCV NS5B inhibitors with IC(50) values between 22.3 and 39.7 μM. F-3070 and F-3065 displayed potent inhibition of intracellular NS5B activity ...[more]