Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC3288850 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Huang Yan Y Li Wencheng W Yao Xiao X Lin Qi-Jiang QJ Yin Jing-Wen JW Liang Yan Y Heiner Monika M Tian Bin B Hui Jingyi J Wang Gang G
Molecular cell 20120119 4
Mediator complex is an integrative hub for transcriptional regulation. Here we show that Mediator regulates alternative mRNA processing via its MED23 subunit. Combining tandem affinity purification and mass spectrometry, we identified a number of mRNA processing factors that bind to a soluble recombinant Mediator subunit, MED23, but not to several other Mediator components. One of these factors, hnRNP L, specifically interacts with MED23 in vitro and in vivo. Consistently, Mediator partially col ...[more]