Ontology highlight
ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC3288892 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Yu Yiyun Y Liu Yaoyang Y Shi Fu-Dong FD Zou Hejian H Hahn Bevra H BH La Cava Antonio A
Clinical immunology (Orlando, Fla.) 20111115 3
We have previously shown that immune tolerance induced by the anti-DNA Ig peptide pCons in (NZB×NZW)F(1) (NZB/W) lupus mice prolonged survival of treated animals and delayed the appearance of autoantibodies and glomerulonephritis. Part of the protection conferred by pCons could be ascribed to the induction of regulatory T cells (T(Reg)) that suppressed the production of anti-DNA antibodies in a p38 MAPK-dependent fashion. Here we show that another effect of pCons in the induction of immune toler ...[more]