Ontology highlight
ABSTRACT:
SUBMITTER: MacKenzie SH
PROVIDER: S-EPMC3289102 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
MacKenzie Sarah H SH Schipper Joshua L JL Clark A Clay AC
Current opinion in drug discovery & development 20100901 5
Caspases are a family of proteases that are involved in the execution of apoptosis and the inflammatory response. A plethora of diseases occur as a result of the dysregulation of apoptosis and inflammation, and caspases have been targeted as a therapeutic strategy to halt the progression of such diseases. Hundreds of peptide and peptidomimetic inhibitors have been designed and tested, but only a few have advanced to clinical trials because of poor drug-like properties and pharmacological constra ...[more]