Ontology highlight
ABSTRACT:
SUBMITTER: Kato L
PROVIDER: S-EPMC3289292 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Kato Lucia L Begum Nasim A NA Burroughs A Maxwell AM Doi Tomomitsu T Kawai Jun J Daub Carsten O CO Kawaguchi Takahisa T Matsuda Fumihiko F Hayashizaki Yoshihide Y Honjo Tasuku T
Proceedings of the National Academy of Sciences of the United States of America 20120130 7
Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. AID is also known to target nonimmunoglobulin genes and introduce mutations or chromosomal translocations, eventually causing tumors. To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide approaches. Along with known AID targets, this screen identified a set of unique genes (SNHG3, MALAT1, BCL7A ...[more]