Ontology highlight
ABSTRACT:
SUBMITTER: Traum D
PROVIDER: S-EPMC3289398 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Traum Daniel D Timothee Patricia P Silver Jonathan J Rose-John Stefan S Ernst Matthias M LaRosa David F DF
Journal of leukocyte biology 20111202 3
It is reported that human and mouse mast cells express the IL-27R, which consists of WSX-1 (the IL-27Rα subunit) and the signal-transducing subunit gp130. Although it has been proposed that IL-27 may negatively regulate mast cell-dependent, immediate hypersensitivity responses directly, this has yet to be examined specifically. We found that mouse BMMC and primary peritoneal mast cells are unresponsive to IL-27. Consistent with this, gp130 protein in resting BMMC was not on the cell surface to a ...[more]