Ontology highlight
ABSTRACT:
SUBMITTER: Davis SP
PROVIDER: S-EPMC3289509 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Davis Shevaun P SP Amrein Matthias M Gillrie Mark R MR Lee Kristine K Muruve Daniel A DA Ho May M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111121 3
The adhesion of infected red blood cells (IRBCs) to microvascular endothelium is critical in the pathogenesis of severe malaria. Here we used atomic force and confocal microscopy to examine the adhesive forces between IRBCs and human dermal microvascular endothelial cells. Initial contact of the cells generated a mean ± sd adhesion force of 167 ± 208 pN from the formation of single or multiple bonds with CD36. The strength of adhesion increased by 5- to 6-fold within minutes of contact through a ...[more]