Ontology highlight
ABSTRACT:
SUBMITTER: Lougaris V
PROVIDER: S-EPMC3289902 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Lougaris Vassilios V Baronio Manuela M Vitali Massimiliano M Tampella Giacomo G Soresina Annarosa A Badolato Raffaele R Plebani Alessandro A
TheScientificWorldJournal 20120201
Broad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID). CXCL16, a surface receptor, was recently shown to influence cell responses to CpG. We evaluated the expression and function of CXCL16 on B cells from healthy controls and CVID patients. We report that CXCL16 is normally expressed on B cells throughout peripheral maturation. Decreased B cell expression of CXCL16 was observed in a subgroup of CVID pati ...[more]