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B cell responses to CpG correlate with CXCL16 expression levels in common variable immunodeficiency.


ABSTRACT: Broad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID). CXCL16, a surface receptor, was recently shown to influence cell responses to CpG. We evaluated the expression and function of CXCL16 on B cells from healthy controls and CVID patients. We report that CXCL16 is normally expressed on B cells throughout peripheral maturation. Decreased B cell expression of CXCL16 was observed in a subgroup of CVID patients that correlated with defective in vitro responses to CpG (such as upregulation of CD69, CD86, AICDA, IL-6, and TLR9). Our data suggest that expression levels of a surface receptor, namely, CXCL16, correlate with B cell responses mediated by TLR9 in common variable immunodeficiency.

SUBMITTER: Lougaris V 

PROVIDER: S-EPMC3289902 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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B cell responses to CpG correlate with CXCL16 expression levels in common variable immunodeficiency.

Lougaris Vassilios V   Baronio Manuela M   Vitali Massimiliano M   Tampella Giacomo G   Soresina Annarosa A   Badolato Raffaele R   Plebani Alessandro A  

TheScientificWorldJournal 20120201


Broad Toll-like receptor 9 (TLR9) signalling defects after CpG in vitro stimulation have been described in common variable immunodeficiency (CVID). CXCL16, a surface receptor, was recently shown to influence cell responses to CpG. We evaluated the expression and function of CXCL16 on B cells from healthy controls and CVID patients. We report that CXCL16 is normally expressed on B cells throughout peripheral maturation. Decreased B cell expression of CXCL16 was observed in a subgroup of CVID pati  ...[more]

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