Ontology highlight
ABSTRACT:
SUBMITTER: Myllykoski M
PROVIDER: S-EPMC3290555 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Myllykoski Matti M Raasakka Arne A Han Huijong H Kursula Petri P
PloS one 20120229 2
The 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is a highly abundant membrane-associated enzyme in the myelin sheath of the vertebrate nervous system. CNPase is a member of the 2H phosphoesterase family and catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates; however, its physiological substrate and function remain unknown. It is likely that CNPase participates in RNA metabolism in the myelinating cell. We solved crystal structures of the phosphodiesterase do ...[more]