Proteasomes and protein conjugation across domains of life.
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ABSTRACT:
SUBMITTER: Maupin-Furlow J
PROVIDER: S-EPMC3291102 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Proteasomes and protein conjugation across domains of life.
Nature reviews. Microbiology 20111219 2
Like other energy-dependent proteases, proteasomes, which are found across the three domains of life, are self-compartmentalized and important in the early steps of proteolysis. Proteasomes degrade improperly synthesized, damaged or misfolded proteins and hydrolyse regulatory proteins that must be specifically removed or cleaved for cell signalling. In eukaryotes, proteins are typically targeted for proteasome-mediated destruction through polyubiquitylation, although ubiquitin-independent pathwa ...[more]
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