Ontology highlight
ABSTRACT:
SUBMITTER: Khatri A
PROVIDER: S-EPMC3291184 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Khatri Amit A Brundage Richard C RC Hull Jessica M JM Williams Brent W BW Yee Douglas D Kirstein Mark N MN
The AAPS journal 20111119 1
Agents that block insulin-like growth factor (IGF) signaling are under investigation in clinical trials. Antitumor effects are likely to be enhanced when combined with other agents, but administration sequence effects on activity are not well-described. Three breast cancer cell lines (MCF-7, MDA-MB-231, and Hs-578T) were treated with Gemcitabine and small molecule receptor tyrosine kinase inhibitor cis-3-[3-(4-methyl-piperazin-l-yl)-cyclobutyl]1-(2-phenyl-quinolin-7-yl)-imidazo [1,5-a]pyrazin-8- ...[more]