Ontology highlight
ABSTRACT:
SUBMITTER: Tien AL
PROVIDER: S-EPMC3291200 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Tien Amy L AL Senbanerjee Sucharita S Kulkarni Atul A Mudbhary Raksha R Goudreau Bernadette B Ganesan Shridar S Sadler Kirsten C KC Ukomadu Chinweike C
The Biochemical journal 20110401 1
UHRF1 [ubiquitin-like protein, containing PHD (plant homeodomain) and RING finger domains 1] is required for cell cycle progression and epigenetic regulation. In the present study, we show that depleting cancer cells of UHRF1 causes activation of the DNA damage response pathway, cell cycle arrest in G2/M-phase and apoptosis dependent on caspase 8. The DNA damage response in cells depleted of UHRF1 is illustrated by: phosphorylation of histone H2AX on Ser139, phosphorylation of CHK (checkpoint ki ...[more]