Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged.

ABSTRACT: We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility index quantify differences within backbone flexibility, whereas changes in the cooperativity correlation quantify differences within pairwise mechanical couplings. Regardless of metric, the same general conclusions are drawn. That is, small structural perturbations introduced by single point mutations have a frequent and pronounced affect on lysozyme flexibility that can extend over long distances. Specifically, an appreciable change occurs in backbone flexibility for 48% of the residues, and a change in cooperativity occurs in 42% of residue pair

SUBMITTER: Verma D 

PROVIDER: S-EPMC3291535 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature