Ontology highlight
ABSTRACT:
SUBMITTER: Choorapoikayil S
PROVIDER: S-EPMC3291645 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Choorapoikayil Suma S Kuiper Raoul V RV de Bruin Alain A den Hertog Jeroen J
Disease models & mechanisms 20111109 2
PTEN is an essential tumor suppressor that antagonizes Akt/PKB signaling. The zebrafish genome encodes two Pten genes, ptena and ptenb. Here, we report that zebrafish mutants that retain a single wild-type copy of ptena or ptenb (ptena(+/-)ptenb(-/-) or ptena(-/-)ptenb(+/-)) are viable and fertile. ptena(+/-)ptenb(-/-) fish develop tumors at a relatively high incidence (10.2%) and most tumors developed close to the eye (26/30). Histopathologically, the tumor masses were associated with the retro ...[more]