Ontology highlight
ABSTRACT:
SUBMITTER: Ashton GH
PROVIDER: S-EPMC3291717 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Developmental cell 20100801 2
The intestinal epithelium has a remarkable capacity to regenerate after injury and DNA damage. Here, we show that the integrin effector protein Focal Adhesion Kinase (FAK) is dispensable for normal intestinal homeostasis and DNA damage signaling, but is essential for intestinal regeneration following DNA damage. Given Wnt/c-Myc signaling is activated following intestinal regeneration, we investigated the functional importance of FAK following deletion of the Apc tumor suppressor protein within t ...[more]