Gene-expression signatures: biomarkers toward diagnosing multiple sclerosis.
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ABSTRACT:
SUBMITTER: Tossberg JT
PROVIDER: S-EPMC3291793 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Publications
Gene-expression signatures: biomarkers toward diagnosing multiple sclerosis.
Tossberg J T JT Crooke P S PS Crooke P S PS Henderson M A MA Sriram S S Mrelashvili D D Chitnis S S Polman C C Vosslamber S S Verweij C L CL Olsen N J NJ Aune T M TM
Genes and immunity 20110922 2
Identification of biomarkers contributing to disease diagnosis, classification or prognosis could be of considerable utility. For example, primary methods to diagnose multiple sclerosis (MS) include magnetic resonance imaging and detection of immunological abnormalities in cerebrospinal fluid. We determined whether gene-expression differences in blood discriminated MS subjects from comparator groups, and identified panels of ratios that performed with varying degrees of accuracy depending upon c ...[more]
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