Identification of hot and cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts.
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ABSTRACT:
SUBMITTER: Das S
PROVIDER: S-EPMC3291883 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Identification of hot and cold spots in genome of Mycobacterium tuberculosis using Shewhart Control Charts.
Das Sarbashis S Duggal Priyanka P Roy Rahul R Myneedu Vithal P VP Behera Digamber D Prasad Hanumanthappa K HK Bhattacharya Alok A
Scientific reports 20120302
The organization of genomic sequences is dynamic and undergoes change during the process of evolution. Many of the variations arise spontaneously and the observed genomic changes can either be distributed uniformly throughout the genome or be preferentially localized to some regions (hot spots) compared to others. Conversely cold spots may tend to accumulate very few variations or none at all. In order to identify such regions statistically, we have developed a method based on Shewhart Control C ...[more]
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