Ontology highlight
ABSTRACT:
SUBMITTER: Huang W
PROVIDER: S-EPMC3292424 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Huang Weijiao W Choi Wooyoung W Hu Wanqiu W Mi Na N Guo Qiang Q Ma Meisheng M Liu Mei M Tian Yuan Y Lu Peilong P Wang Feng-Liang FL Deng Haiteng H Liu Lei L Gao Ning N Yu Li L Shi Yigong Y
Cell research 20120207 3
The Beclin 1 gene is a haplo-insufficient tumor suppressor and plays an essential role in autophagy. However, the molecular mechanism by which Beclin 1 functions remains largely unknown. Here we report the crystal structure of the evolutionarily conserved domain (ECD) of Beclin 1 at 1.6 Å resolution. Beclin 1 ECD exhibits a previously unreported fold, with three structural repeats arranged symmetrically around a central axis. Beclin 1 ECD defines a novel class of membrane-binding domain, with a ...[more]