No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations.

ABSTRACT:

Background

Behcet's disease is known as a recurrent, multisystem inflammation and immune-related disease. Protein tyrosine phosphatase non-receptor 22 (PTPN22) is a key negative regulator of T lymphocytes and polymorphisms of the PTPN22 gene have been shown to be associated with various immune-related diseases. The present study was performed to assess the association between PTPN22 polymorphisms and Behcet's disease in two Chinese Han populations.

Methodology/principal findings

A total of 516 patients with ocular Behcet's disease and 690 healthy controls from two Chinese Han populations were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method for three single nucleotide polymorphisms (SNPs). Hardy-Weinberg equilibrium was te

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC3292549 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature