Ontology highlight
ABSTRACT:
SUBMITTER: Noinaj N
PROVIDER: S-EPMC3292680 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Nature 20120212 7387
Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane. The transport system consists of TbpA, an integral outer membrane protein, and TbpB, a co-receptor attached to the cell surface; both proteins are potentially important vaccine and therapeutic targets. Two key questions driving Neisseria research are how human transferrin is ...[more]