Ontology highlight
ABSTRACT:
SUBMITTER: Hicks C
PROVIDER: S-EPMC3292850 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hicks Chindo C Kumar Ranjit R Pannuti Antonio A Miele Lucio L
Breast cancer : basic and clinical research 20120220
Variable response and resistance to tamoxifen treatment in breast cancer patients remains a major clinical problem. To determine whether genes and biological pathways containing SNPs associated with risk for breast cancer are dysregulated in response to tamoxifen treatment, we performed analysis combining information from 43 genome-wide association studies with gene expression data from 298 ER(+) breast cancer patients treated with tamoxifen and 125 ER(+) controls. We identified 95 genes which d ...[more]