Ontology highlight
ABSTRACT:
SUBMITTER: Streeper RS
PROVIDER: S-EPMC3292902 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Streeper Ryan S RS Grueter Carrie A CA Salomonis Nathan N Cases Sylvaine S Levin Malin C MC Koliwad Suneil K SK Zhou Ping P Hirschey Mattew D MD Verdin Eric E Farese Robert V RV
Aging 20120101 1
Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and m ...[more]